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Vitamin D is both a nutrient nosotros eat and a hormone our bodies make. It is a fat-soluble vitamin that has long been known to assistance the torso absorb and retain calcium and phosphorus; both are critical for building bone. Also, laboratory studies show that vitamin D tin reduce cancer cell growth, aid control infections and reduce inflammation. Many of the body's organs and tissues have receptors for vitamin D, which advise of import roles beyond os health, and scientists are actively investigating other possible functions.

Few foods naturally comprise vitamin D, though some foods are fortified with the vitamin. For most people, the all-time mode to go enough vitamin D is taking a supplement because it is hard to eat enough through food. Vitamin D supplements are available in ii forms: vitamin D2 ("ergocalciferol" or pre-vitamin D) and vitamin D3 ("cholecalciferol"). Both are also naturally occurring forms that are  produced in the presence of the sunday's ultraviolet-B (UVB) rays, hence its nickname, "the sunshine vitamin," but D2 is produced in plants and fungi and D3 in animals, including humans. Vitamin D product in the skin is the primary natural source of vitamin D, but many people have bereft levels because they live in places where sunlight is limited in winter, or considering they have limited sun exposure due to existence inside much of the fourth dimension. Also, people with darker pare tend to have lower blood levels of vitamin D because the paint (melanin) acts similar a shade, reducing production of vitamin D (and besides reducing dissentious effects of sunlight on skin, including peel cancer).

Recommended Amounts

The Recommended Dietary Allowance for vitamin D provides the daily amount needed to maintain healthy bones and normal calcium metabolism in healthy people. It assumes minimal lord's day exposure.

RDA: The Recommended Dietary Allowance for adults 19 years and older is 600 IU daily for men and women, and for adults >70 years it is 800 IU daily.

UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful furnishings on wellness. The UL for vitamin D for adults and children ages 9+ is iv,000 IU.

Many people may non be meeting the minimum requirement for the vitamin. NHANES information found that the median intake of vitamin D from food and supplements in women ages 51 to 71 years was 308 IU daily, but but 140 IU from food alone (including fortified products). [one] Worldwide, an estimated 1 billion people have inadequate levels of vitamin D in their blood, and deficiencies tin exist found in all ethnicities and historic period groups. [ii-four]  In industrialized countries, doctors are seeing the resurgence of rickets, the os-weakening disease that had been largely eradicated through vitamin D fortification. [5-vii] There is scientific argue most how much vitamin D people demand each day and what the optimal serum levels should be to prevent disease. The Institute of Medicine (IOM) released in November 2010 recommendations increasing the daily vitamin D intake for children and adults in the U.S. and Canada, to 600 IU per twenty-four hours. [1] The report as well increased the upper limit from two,000 to 4,000 IU per day. Although some groups such as The Endocrine Society recommend 1,500 to two,000 IU daily to reach adequate serum levels of vitamin D, the IOM felt at that place was not plenty show to establish a cause and upshot link with vitamin D and health benefits other than for bone health.  Since that time,  new evidence has supported other benefits of consuming an adequate corporeality of vitamin D, although there is still not consensus on the amount considered to be adequate.

Vitamin D and Health

The office of vitamin D in disease prevention is a pop expanse of research, only clear answers most the benefit of taking amounts beyond the RDA are non conclusive. Although observational studies run into a stiff connexion with lower rates of certain diseases in populations that live in sunnier climates or accept higher serum levels of vitamin D, clinical trials that requite people vitamin D supplements to impact a particular disease are all the same inconclusive. This may exist due to different study designs, differences in the absorption rates of vitamin D in different populations, and dissimilar dosages given to participants. Acquire more near the research on vitamin D and specific wellness atmospheric condition and diseases:

Os health and muscle strength

Several studies link depression vitamin D blood levels with an increased risk of fractures in older adults, and they suggest that vitamin D supplementation may forestall such fractures—as long as it is taken in a high plenty dose. [8-12]

A meta-analysis of 12 randomized controlled trials that included more than than 42,000 people 65+ years of historic period, nigh of them women, looked at vitamin D supplementation with or without calcium, and with calcium or a placebo. Researchers found that higher intakes of vitamin D supplements—about 500-800 IU per day—reduced hip and not-spine fractures by about 20%, while lower intakes (400 IU or less) failed to offer any fracture prevention benefit. [12]

A systematic review looked at the issue of vitamin D supplements taken with or without calcium on the prevention of hip fractures (primary outcome) and fractures of any type (secondary outcome) in older men and postmenopausal women 65+ years of age. Information technology included 53 clinical trials with 91,791 participants who lived independently or in a nursing dwelling or hospital. It did not find a stiff association betwixt vitamin D supplements alone and prevention of fractures of whatsoever type. However, it did detect a minor protective result from all types of fractures when vitamin D was taken with calcium. All of the trials used vitamin D supplements containing 800 IU or less. [13]

Vitamin D may likewise help increase muscle strength, which in turn helps to prevent falls, a mutual problem that leads to substantial disability and death in older people. [fourteen–16] A combined analysis of multiple studies plant that taking 700 to i,000 IU of vitamin D per 24-hour interval lowered the gamble of falls past nineteen%, just taking 200 to 600 IU per day did non offering any such protection. [17]

Though taking 800-ane,000 IU daily may have do good for bone health in older adults, it is important to be cautious of very high dosage supplements. A clinical trial that gave women 70+ years of historic period a once-yearly dosage of vitamin D at 500,000 IU for five years caused a xv% increased risk of falls and a 26% college fracture risk than women who received a placebo. [18] It was speculated that super-saturating the body with a very high dose given infrequently may have actually promoted lower blood levels of the agile form of vitamin D that might not have occurred with smaller, more frequent doses. [thirteen]

Cancer

Virtually 30 years agone, researchers noticed an intriguing relationship between colon cancer deaths and geographic location: People who lived at higher latitudes, such as in the northern U.Southward., had higher rates of death from colon cancer than people who lived closer to the equator. [19] Many scientific hypotheses about vitamin D and affliction stalk from studies that have compared solar radiations and disease rates in dissimilar countries. These studies can be a good starting point for other research but don't provide the most definitive information. The sun's UVB rays are weaker at college latitudes, and in plow, people's vitamin D blood levels in these locales tend to be lower. This led to the hypothesis that low vitamin D levels might somehow increment colon cancer risk. [3]

Animal and laboratory studies take found that vitamin D tin can inhibit the development of tumors and slow the growth of existing tumors including those from the breast, ovary, colon, prostate, and brain. In humans, epidemiological studies testify that college serum levels of vitamin D are associated with substantially lower rates of colon, pancreatic, prostate, and other cancers, with the show strongest for colorectal cancer. [20-32]

Yet, clinical trials have not found a consequent association:

The Women'south Wellness Initiative trial, which followed roughly 36,000 women for an average of 7 years, failed to discover whatever reduction in colon or breast cancer adventure in women who received daily supplements of 400 IU of vitamin D and 1,000 mg of calcium, compared with those who received a placebo. [33,34] Limitations of the study were suggested: 1) the relatively low dose of vitamin D given, two) some people in the placebo group decided on their own to take extra calcium and vitamin D supplements, minimizing the differences betwixt the placebo grouping and the supplement group, and 3) almost one-third of the women assigned to vitamin D did non take their supplements. four) seven years may be too short to expect a reduction in cancer risk. [35,36]

A large clinical trial called the VITamin D and OmegA-3 TriaL (VITAL) followed 25,871 men and women 50+ years of age free of any cancers at the start of the written report who took either a two,000 IU vitamin D supplement or placebo daily for a median of five years. [37] The findings did not bear witness significantly different rates of breast, prostate, and colorectal cancer between the vitamin D and placebo groups. The authors noted that a longer follow-up period would exist necessary to improve assess potential effects of supplementation, every bit many cancers take at least 5-10 years to develop.

Although vitamin D does not seem to be a major factor in reducing cancer incidence, show including that from randomized trials suggests that having higher vitamin D condition may better survival if one develops cancer.  In the VITAL trial, a lower expiry rate from cancer was observed in those assigned to accept vitamin D, and this benefit seemed to increase over time since starting on vitamin D. A meta-analysis of randomized trials of vitamin D, which included the VITAL written report, constitute a 13% statistically significant lower risk of cancer mortality in those assigned to vitamin D compared to placebo. [38] These findings are consistent with observational data, which suggest that vitamin D may accept a stronger result on cancer progression than for incidence.

Heart disease

The heart is basically a large muscle, and similar skeletal muscle, it has receptors for vitamin D. [39] Immune and inflammatory cells that play a role in cardiovascular illness conditions like atherosclerosis are regulated by vitamin D. [40] The vitamin also helps to keep arteries flexible and relaxed, which in turn helps to command loftier blood pressure. [41]

In the Health Professionals Follow-upward Study nearly l,000 healthy men were followed for x years. [42] Those who had the lowest levels of vitamin D were twice every bit likely to have a heart attack equally men who had the highest levels. Meta-analyses of epidemiological studies accept found that people with the lowest serum levels of vitamin D had a significantly increased risk of strokes and whatsoever heart illness issue compared with those with the highest levels. [40;43-46]

Nonetheless, taking vitamin D supplements has not been plant to reduce cardiovascular risk. A meta-analysis of 51 clinical trials did not demonstrate that vitamin D supplementation lowered the take a chance of heart set on, stroke, or deaths from cardiovascular affliction. [47] The VITamin D and OmegA-3 TriaL (VITAL) came to the same determination; it followed 25,871 men and women gratuitous of cardiovascular disease who took either a 2,000 IU vitamin D supplement or placebo daily for a median of five years. No association was establish betwixt taking the supplements and a lower risk of major cardiovascular events (heart assault, stroke, or expiry from cardiovascular causes) compared with the placebo. [37]

Blazon two diabetes

Vitamin D deficiency may negatively affect the biochemical pathways that lead to the development of Type 2 diabetes (T2DM), including impairment of beta cell function in the pancreas, insulin resistance, and inflammation. Prospective observational studies have shown that higher vitamin D blood levels are associated with lower rates of T2DM. [48]

More than 83,000 women without diabetes at baseline were followed in the Nurses' Health Report for the development of T2DM. Vitamin D and calcium intakes from diet and supplements were assessed throughout the twenty-year study. [49] The authors found that when comparing the women with the highest intakes of vitamin D from supplements with women with the everyman intakes, in that location was a thirteen% lower take chances of developing T2DM. The upshot was even stronger when vitamin D was combined with calcium: in that location was a 33% lower risk of T2DM in women when comparing the highest intakes of calcium and vitamin D from supplements (>ane,200 mg, >800 IU daily) with the lowest intakes (<600 mg, 400 IU).

A randomized clinical trial gave 2,423 adults who had prediabetes either 4000 IU of vitamin D or a placebo daily for two years. The majority of participants did non have vitamin D deficiency at the start of the study. At two years, vitamin D blood levels in the supplement versus placebo group was 54.3 ng/mL versus 28.2 ng/mL, respectively, but no significant differences were observed in rates of T2DM at the 2.5 year follow-upwardly. [fifty] The authors noted that a lack of effect of vitamin D may have been due to the majority of participants having vitamin D blood levels in a normal range of greater than 20 ng/mL, which is considered an acceptable level to reduce wellness risks.  Notably, amongst the participants who had the lowest blood levels of vitamin D at the beginning of the study, vitamin D supplementation did reduce chance of diabetes. This is consistent with the important concept that taking additional vitamin D may not benefit those who already have adequate claret levels, only those with initially low blood levels may benefit.

Allowed function

Vitamin D's role in regulating the immune system has led scientists to explore two parallel research paths: Does vitamin D deficiency contribute to the evolution of multiple sclerosis, blazon i diabetes, and other so-chosen "autoimmune" diseases, where the body'south immune system attacks its own organs and tissues? And could vitamin D supplements help boost our body's defenses to fight infectious disease, such every bit tuberculosis and seasonal flu?

Multiple Sclerosis
The rate of multiple sclerosis (MS) is increasing in both developed and developing countries, with an unclear cause. Nevertheless, a person's genetic background plus ecology factors including inadequate vitamin D and UVB exposure have been identified to increase risk. [51] Vitamin D was get-go proposed over 40 years ago as having a role in MS given observations at the fourth dimension including that rates of MS were much college far northward (or far s) of the equator than in sunnier climates, and that geographic regions with diets high in fish had lower rates of MS. [52] A prospective report of dietary intake of vitamin D institute women with daily intake in a higher place 400 IU had a 40% lower risk of MS. [53] In a study among healthy young adults in the Usa, white men and women with the highest vitamin D serum levels had a 62% lower hazard of developing MS than those with the lowest vitamin D levels. [54] The written report didn't find this effect among black men and women, possibly because in that location were fewer black study participants and most of them had depression vitamin D levels, making it harder to find any link between vitamin D and MS if one exists. Another prospective study in young adults from Sweden also found a 61% lower risk of MS with higher serum vitamin D levels; [55] and a prospective study among young Finnish women found that low serum vitamin D levels were associated with a 43% increased hazard of MS. [56] In prospective studies of persons with MS, college vitamin D levels take been associated with reduced disease activity and progression. [57,58] While several clinical trials are underway to examine vitamin D as a treatment in persons with MS, there are no clinical trials aimed at prevention of MS, likely considering MS is a rare disease and the trial would need to be large and of long duration. Collectively, the current show suggests that low vitamin D may have a causal role in MS and if and then, approximately xl% of cases may be prevented by correcting vitamin D insufficiency. [59] This determination has been strengthened substantially past contempo evidence that genetically adamant low levels of vitamin D predict higher take a chance of multiple sclerosis.

Type 1 Diabetes
Blazon ane diabetes (T1D) is another disease that varies with geography—a child in Finland is almost 400 times more likely to develop T1D than a child in Venezuela. [threescore] While this may largely be due to genetic differences, some studies suggest that T1D rates are lower in sunnier areas. Early evidence suggesting that vitamin D may play a role in T1D comes from a xxx-year report that followed more than x,000 Finnish children from birth: Children who regularly received vitamin D supplements during infancy had a nearly 90% lower risk of developing blazon one diabetes than those who did non receive supplements. [61] Yet, multiple studies examining the association between dietary vitamin D or trials supplementing children at high gamble for T1D with vitamin D have produced mixed and inconclusive results [62] Approximately 40% of T1D cases begin in adulthood. A prospective written report amid healthy immature adults in the Us found that white individuals with the highest levels of serum vitamin D had a 44% lower risk of developing T1D in adulthood than those with the lowest levels. [63] No randomized controlled trials on vitamin D and adult onset T1D take been conducted, and it is not clear that they would exist possible to carry. More enquiry is needed in this surface area.

Flu and the Common Common cold
The flu virus wreaks the most havoc in the winter, abating in the summer months. This seasonality led a British medico to hypothesize that a sunlight-related "seasonal stimulus" triggered influenza outbreaks. [64] More than 20 years after this initial hypothesis, several scientists published a newspaper suggesting that vitamin D may be the seasonal stimulus. [65] Amongst the bear witness they cite:

• • Vitamin D levels are lowest in the winter months. [65]
  • The agile form of vitamin D tempers the damaging inflammatory response of some white claret cells, while it besides boosts immune cells' production of microbe-fighting proteins. [65]
  • Children who have vitamin D-deficiency rickets are more likely to get respiratory infections, while children exposed to sunlight seem to take fewer respiratory infections. [65]
  • Adults who have depression vitamin D levels are more likely to report having had a recent coughing, cold, or upper respiratory tract infection. [66]

A randomized controlled trial in Japanese schoolhouse children tested whether taking daily vitamin D supplements would prevent seasonal influenza. [67] The trial followed about 340 children for four months during the height of the winter flu flavour. Half of the study participants received pills that contained 1,200 IU of vitamin D; the other one-half received placebo pills. Researchers found that type A influenza rates in the vitamin D group were about xl% lower than in the placebo grouping; in that location was no significant deviation in type B flu rates.

Although randomized controlled trials exploring the potential of vitamin D to prevent other astute respiratory infections take yielded mixed results, a large meta-analysis of private participant information indicated that daily or weekly vitamin D supplementation lowers hazard of astute respiratory infections. [68] This effect was especially prominent for very scarce individuals.

The findings from this large meta-analysis take raised the possibility that low vitamin D levels may also increase chance of or severity of novel coronavirus 2022 (COVID-nineteen) infection. Although at that place is no straight evidence on this result because this such a new illness, avoiding low levels of vitamin D makes sense for this and other reasons. Thus, if at that place is reason to believe that levels might be depression, such equally having darker peel or limited dominicus exposure, taking a supplement of chiliad or 2000 IU per day is reasonable. This amount is now part of many standard multiple vitamin supplements and cheap.

More than research is needed before we can definitively say that vitamin D protects against the flu and other acute respiratory infections. Even if vitamin D has some benefit, don't skip your flu shot. And when it comes to limiting risk of COVID-19, information technology is important to practice careful social distancing and hand washing.

Tuberculosis
Earlier the advent of antibiotics, sunlight and sun lamps were part of the standard handling for tuberculosis (TB). [69] More recent research suggests that the "sunshine vitamin" may be linked to TB risk. Several case-control studies, when analyzed together, suggest that people diagnosed with tuberculosis have lower vitamin D levels than salubrious people of like age and other characteristics. [lxx] Such studies exercise not follow individuals over time, and so they cannot tell usa whether vitamin D deficiency led to the increased TB take a chance or whether taking vitamin D supplements would prevent TB. There are also genetic differences in the receptor that binds vitamin D, and these differences may influence TB risk. [71] Again, more than research is needed.

Other A utoimmune Weather
The Vitamin D and Omega 3 trial (VITAL), a randomized double-blind placebo-controlled trial post-obit more than 25,000 men and women ages 50 and older, found that taking vitamin D supplements (2,000 IU/twenty-four hour period) for five years, or vitamin D supplements with marine omega-three fat acids (ane,000 mg/mean solar day), reduced the incidence of autoimmune diseases by about 22%, compared with a placebo. Autoimmune conditions observed included rheumatoid arthritis, psoriasis, polymyalgia rheumatica, and autoimmune thyroid diseases (Hashimoto's thyroiditis, Graves' affliction). [78]The doses in these supplements are widely available and generally well-tolerated. The authors recommended additional trials to test the effectiveness of these supplements in younger populations and those at loftier adventure of developing autoimmune diseases.

Take a chance of premature death

A promising written report in the Archives of Internal Medicine suggests that taking vitamin D supplements may reduce overall bloodshed rates: A combined analysis of multiple studies found that taking modest levels of vitamin D supplements was associated with a statistically significant seven% reduction in bloodshed from whatsoever cause. [72] The analysis looked at the findings from 18 randomized controlled trials that enrolled a total of nearly lx,000 study participants; most of the study participants took between 400 and 800 IU of vitamin D per twenty-four hour period for an boilerplate of v years. Go along in mind that this analysis has several limitations, chief amid them the fact that the studies it included were not designed to explore mortality in full general, or explore specific causes of death.  A recent meta-assay suggests that this reduction in mortality is driven mostly by a reduction in cancer mortality. [38] More enquiry is needed before any wide claims can be made about vitamin D and bloodshed. [73]

Food Sources

Few foods are naturally rich in vitamin D3. The best sources are the flesh of fatty fish and fish liver oils. Smaller amounts are found in egg yolks, cheese, and beefiness liver. Sure mushrooms contain some vitamin D2; in addition some commercially sold mushrooms contain college amounts of D2 due to intentionally beingness exposed to high amounts of ultraviolet light. Many foods and supplements are fortified with vitamin D like dairy products and cereals.

• Cod liver oil
• Salmon
• Swordfish
• Tuna fish
• Orangish juice fortified with vitamin D
• Dairy and constitute milks fortified with vitamin D
• Sardines
• Beef liver
• Egg yolk
• Fortified cereals

Is There a Difference Between Vitamin D3 and Vitamin D2 Supplements?

If you purchase vitamin D supplements, you may encounter ii different forms: vitamin D2 and vitamin D3. Vitamin D2 is made from plants and is establish in fortified foods and some supplements. Vitamin D3 is naturally produced in the human torso and is institute in brute foods. There is ongoing debate whether vitamin D3 "cholecalciferol" is better than vitamin D2 "ergocalciferol" at increasing claret levels of the vitamin. A meta-assay of randomized controlled trials that compared the effects of vitamin D2 and D3 supplements on blood levels constitute that D3 supplements tended to raise blood concentrations of the vitamin more than and sustained those levels longer than D2. [74,75] Some experts cite vitamin D3 equally the preferred form as it is naturally produced in the trunk and found in virtually foods that naturally contain the vitamin.

Ultraviolet Light

Vitamin D3 can be formed when a chemical reaction occurs in human pare, when a steroid chosen 7-dehydrocholesterol is broken downwardly past the sun's UVB lite or and then-called "tanning" rays. The amount of the vitamin absorbed tin vary widely. The following are atmospheric condition that subtract exposure to UVB light and therefore lessen vitamin D absorption:

• Use of sunscreen; correctly practical sunscreen tin can reduce vitamin D absorption past more than xc%. [76]
• Wearing full wearable that covers the pare.
• Spending limited fourth dimension outdoors.
• Darker skin tones due to having higher amounts of the pigment melanin, which acts as a type of natural sunscreen. [77]
• Older ages when there is a decrease in seven-dehydrocholesterol levels and changes in skin, and a population that is likely to spend more fourth dimension indoors.
• Certain seasons and living in northern latitudes above the equator where UVB light is weaker. [76] In the northern hemisphere, people who live in Boston (U.S.), Edmonton (Canada), and Bergen (Norway) tin't brand enough vitamin D from the sun for 4, v, and 6 months out of the year, respectively. [76] In the southern hemisphere, residents of Buenos Aires (Argentina) and Cape Town (S Africa) brand far less vitamin D from the dominicus during their wintertime months (June through August) than they can during their bound and summer months. [76] The body stores vitamin D from summertime sun exposure, merely information technology must concluding for many months. By late winter, many people in these college-latitude locales are deficient. [77]

Annotation that because ultraviolet rays can crusade peel cancer, it is important to avert excessive sun exposure and in general, tanning beds should not exist used.

Signs of Deficiency and Toxicity

Deficiency

Vitamin D deficiency may occur from a lack in the nutrition, poor assimilation, or having a metabolic need for college amounts. If i is not eating enough vitamin D and does not receive enough ultraviolet sun exposure over an extended menstruum (see section above), a deficiency may arise. People who cannot tolerate or practise not consume milk, eggs, and fish, such as those with a lactose intolerance or who follow a vegan diet, are at higher adventure for a deficiency. Other people at high chance of vitamin D deficiency include:

• People with inflammatory bowel disease (ulcerative colitis, Crohn's disease) or other weather condition that disrupt the normal digestion of fat. Vitamin D is a fat-soluble vitamin that depends on the gut's ability to absorb dietary fatty.
• People who are obese tend to accept lower claret vitamin D levels. Vitamin D accumulates in excess fat tissues just is non easily available for utilize by the torso when needed. Higher doses of vitamin D supplementation may be needed to achieve a desirable blood level. Conversely, blood levels of vitamin D ascension when obese people lose weight.
• People who have undergone gastric bypass surgery, which typically removes the upper office of the small intestine where vitamin D is captivated.

Conditions resulting from prolonged vitamin D deficiency:

• Rickets: A condition in infants and children of soft bones and skeletal deformities caused past failure of os tissue to harden.
• Osteomalacia: A condition in adults of weak and softened bones that can be reversed with supplementation. This is different than osteoporosis, in which the bones are porous and breakable and the condition is irreversible.

Toxicity

Vitamin D toxicity most ofttimes occurs from taking supplements. The depression amounts of the vitamin found in food are unlikely to reach a toxic level, and a high amount of sun exposure does non pb to toxicity because excess heat on the skin prevents D3 from forming. It is advised to not take daily vitamin D supplements containing more than than four,000 IU unless monitored under the supervision of your doctor.

Symptoms of toxicity:

• Anorexia
• Weight loss
• Irregular heart beat
• Hardening of claret vessels and tissues due to increased blood levels of calcium, potentially leading to damage of the center and kidneys

Did Yous Know?

• Catching the dominicus's rays in a sunny office or driving in a car unfortunately won't help to obtain vitamin D as window glass completely blocks UVB ultraviolet light.

References

1. Constitute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, D.C.: National Academies Press, 2010. https://www.ncbi.nlm.nih.gov/books/NBK56070/
2. Holick MF. Vitamin D deficiency. New England Journal of Medicine. 2007 Jul 19;357(3):266-81.
3. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Archives of pediatrics & adolescent medicine. 2004 Jun one;158(6):531-7.
4. Lips PT. Worldwide status of vitamin D nutrition. The Periodical of steroid biochemistry and molecular biology. 2010 Jul i;121(1-two):297-300.
5. Robinson PD, Högler W, Craig ME, Verge CF, Walker JL, Piper AC, Woodhead HJ, Cowell CT, Ambler GR. The re-emerging burden of rickets: a decade of experience from Sydney. Athenaeum of Affliction in Childhood. 2006 Jul 1;91(7):564-8.
6. Kreiter SR, Schwartz RP, Kirkman Jr HN, Charlton PA, Calikoglu As, Davenport ML. Nutritional rickets in African American chest-fed infants. The Journal of pediatrics. 2000 Aug i;137(ii):153-7.
7. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy Thou. Vitamin D deficiency in children and its direction: review of current knowledge and recommendations. Pediatrics. 2008 Aug i;122(2):398-417.
8. Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Demand for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. The Journal of Clinical Endocrinology & Metabolism. 2007 April i;92(4):1415-23.
9. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci Due east, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Jama. 2005 May 11;293(18):2257-64.
10. Cauley JA, LaCroix AZ, Wu L, Horwitz G, Danielson ME, Bauer DC, Lee JS, Jackson RD, Robbins JA, Wu C, Stanczyk FZ. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Register of internal medicine. 2008 Aug 19;149(four):242-50.
11. Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon PM, Cummings SR, Hoffman AR, Shikany JM, Barrett‐Connor E, Orwoll Due east. Serum 25‐hydroxyvitamin D and the risk of hip and nonspine fractures in older men. Periodical of Bone and Mineral Research. 2010 Mar;25(3):545-53.
12. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-assay of randomized controlled trials. Archives of internal medicine. 2009 Mar 23;169(6):551-61.
13. Avenell A, Mak JC, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in mail service‐menopausal women and older men. Cochrane Database of Systematic Reviews. 2014(four).
14. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB. Result of vitamin D on falls: a meta-assay. Jama. 2004 Apr 28;291(16):1999-2006.
15. Broe KE, Chen TC, Weinberg J, Bischoff‐Ferrari HA, Holick MF, Kiel DP. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple‐dose study. Journal of the American Geriatrics Guild. 2007 Feb;55(ii):234-ix.
16. Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Athenaeum of internal medicine. 2006 February 27;166(4):424-30.
17. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J. Fall prevention with supplemental and agile forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009 Oct ane;339:b3692.
18. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Immature D, Nicholson GC. Almanac loftier-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Jama. 2010 May 12;303(18):1815-22.
19. Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer?. International periodical of epidemiology. 1980 Sep 1;9(3):227-31.
20. Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Register of epidemiology. 2009 Jul 1;19(vii):468-83.
21. McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang One thousand, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ. Circulating vitamin D and colorectal cancer risk: an international pooling project of 17 cohorts. JNCI: Journal of the National Cancer Institute. 2022 Feb 1;111(ii):158-69.
22. Yin L, Grandi Due north, Raum E, Haug U, Arndt V, Brenner H. Meta‐analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Alimentary pharmacology & therapeutics. 2009 Jul;30(2):113-25.
23. Wu Grand, Feskanich D, Fuchs CS, Willett WC, Hollis BW, Giovannucci EL. A nested instance–command study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. Journal of the National Cancer Institute. 2007 Jul 18;99(14):1120-9.
24. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin Yard, Newmark HL, Giovannucci Due east, Wei M, Holick MF. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. American journal of preventive medicine. 2007 Mar ane;32(3):210-vi.
25. Giovannucci E. Epidemiological evidence for vitamin D and colorectal cancer. Journal of Bone and Mineral Inquiry. 2007 Dec;22(S2):V81-5.
26. Lin J, Zhang SM, Melt NR, Manson JE, Lee IM, Buring JE. Intakes of calcium and vitamin D and gamble of colorectal cancer in women. American journal of epidemiology. 2005 April xv;161(eight):755-64.
27. Huncharek M, Muscat J, Kupelnick B. Colorectal cancer run a risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutrition and cancer. 2008 Dec 31;61(1):47-69.
28. Bertone-Johnson ER, Chen WY, Holick MF, Hollis BW, Colditz GA, Willett WC, Hankinson SE. Plasma 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiology and Prevention Biomarkers. 2005 Aug ane;14(8):1991-7.
29. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC. Vitamin D and prevention of breast cancer: pooled analysis. The Journal of steroid biochemistry and molecular biology. 2007 Mar ane;103(three-5):708-11.
30. Lin J, Manson JE, Lee IM, Cook NR, Buring JE, Zhang SM. Intakes of calcium and vitamin D and chest cancer risk in women. Archives of Internal Medicine. 2007 May 28;167(ten):1050-9.
31. Robien Thou, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer adventure in postmenopausal women: the Iowa Women's Wellness Study. Cancer causes & control. 2007 Sep one;18(vii):775-82.
32. Freedman DM, Chang SC, Falk RT, Purdue MP, Huang WY, McCarty CA, Hollis BW, Graubard BI, Berg CD, Ziegler RG. Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiology and Prevention Biomarkers. 2008 Apr one;17(iv):889-94.
33. Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O'sullivan MJ, Margolis KL, Ockene JK, Phillips Fifty, Pottern 50, Prentice RL. Calcium plus vitamin D supplementation and the adventure of colorectal cancer. New England Journal of Medicine. 2006 Feb sixteen;354(7):684-96.
34. Chlebowski RT, Johnson KC, Kooperberg C, Pettinger Grand, Wactawski-Wende J, Rohan T, Rossouw J, Lane D, O'Sullivan MJ, Yasmeen S, Hiatt RA. Calcium plus vitamin D supplementation and the adventure of chest cancer. JNCI: Journal of the National Cancer Institute. 2008 November 19;100(22):1581-91.
35. Holick MF. Calcium plus vitamin D and the risk of colorectal cancer. N Engl J Med. 2006; 354:2287-8; author reply 2287-8.
36. Giovannucci East. Calcium plus vitamin D and the risk of colorectal cancer. N Engl J Med. 2006; 354:2287-8; writer reply 2287-8.
37. Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D, Friedenberg One thousand. Vitamin D supplements and prevention of cancer and cardiovascular disease. New England Periodical of Medicine. 2022 Jan three;380(1):33-44.
38. Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci Eastward. Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Annals of Oncology. 2022 May one;30(five):733-43.
39. Giovannucci E. Expanding roles of vitamin D. J Clin Endocrinol Metab. 2009; 94:418-20.
40. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circulation inquiry. 2022 Jan 17;114(2):379-93.
41. Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Molecular aspects of medicine. 2008 Dec ane;29(vi):361-eight.
42. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Archives of internal medicine. 2008 Jun 9;168(11):1174-80.
43. Pilz S, März West, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H. Association of vitamin D deficiency with eye failure and sudden cardiac death in a large cross-exclusive report of patients referred for coronary angiography. The Periodical of Clinical Endocrinology & Metabolism. 2008 Oct 1;93(10):3927-35.
44. Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, März West. Low vitamin D levels predict stroke in patients referred to coronary angiography. Stroke. 2008 Sep ane;39(nine):2611-three.
45. Booth TW, Lanier PJ. Vitamin D deficiency and risk of cardiovascular disease. Apportionment Res117. 2008;503:511.
46. Dobnig H, Pilz S, Scharnagl H, Renner Due west, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W. Independent association of low serum 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D levels with all-cause and cardiovascular bloodshed. Archives of internal medicine. 2008 Jun 23;168(12):1340-9.
47. Elamin MB, Abu Elnour NO, Elamin KB, Fatourechi MM, Alkatib AA, Almandoz JP, Liu H, Lane MA, Mullan RJ, Hazem A, Erwin PJ. Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. The Periodical of Clinical Endocrinology & Metabolism. 2011 Jul one;96(seven):1931-42.
48. Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin N Am. 2022 Mar;43(one):205-32.
49. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes care. 2006 Mar 1;29(3):650-6.
50. Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, Brodsky I, Ceglia 50, Chadha C, Chatterjee R, Desouza C, Dolor R, Foreyt J, Fuss P, Ghazi A, Hsia DS, Johnson KC, Kashyap SR, Kim S, LeBlanc ES, Lewis MR, Liao E, Neff LM, Nelson J, O'Neil P, Park J, Peters A, Phillips LS, Pratley R, Raskin P, Rasouli N, Robbins D, Rosen C, Vickery EM, Staten M; D2d Research Group. Vitamin D Supplementation and Prevention of Blazon two Diabetes. N Engl J Med. 2022 Aug 8;381(vi):520-530
51. Dobson R, Giovannoni Chiliad. Multiple sclerosis–a review. European periodical of neurology. 2022 Jan;26(1):27-40.
52. Goldberg P. Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence: (A viewpoint) office one: sunlight, dietary factors and epidemiology. International Periodical of Environmental Studies. 1974 Jan 1;6(1):19-27.
53. Munger KL, Zhang SM, O'reilly E, Hernan MA, Olek MJ, Willett WC, Ascherio A. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004 Jan thirteen;62(one):lx-five.
54. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and adventure of multiple sclerosis. Jama. 2006 December 20;296(23):2832-8.
55. Salzer J, Hallmans G, Nyström Thou, Stenlund H, Wadell G, Sundström P. Vitamin D equally a protective factor in multiple sclerosis. Neurology. 2012 Nov 20;79(21):2140-5.
56. Munger KL, Hongell M, Åivo J, Soilu-Hänninen M, Surcel HM, Ascherio A. 25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Motherhood Cohort. Neurology. 2022 Oct 10;89(15):1578-83.
57. Ascherio A, Munger KL, White R, Köchert K, Simon KC, Polman CH, Freedman MS, Hartung HP, Miller DH, Montalbán Ten, Edan Thou. Vitamin D as an early on predictor of multiple sclerosis activeness and progression. JAMA neurology. 2022 Mar one;71(3):306-14.
58. Fitzgerald KC, Munger KL, Köchert K, Arnason BG, Comi Yard, Cook S, Goodin DS, Filippi M, Hartung HP, Jeffery DR, O'Connor P. Association of vitamin D levels with multiple sclerosis activity and progression in patients receiving interferon beta-1b. JAMA neurology. 2022 Dec 1;72(12):1458-65.
59. Ascherio A, Munger KL. Epidemiology of multiple sclerosis: from chance factors to prevention—an update. InSeminars in neurology 2022 April (Vol. 36, No. 02, pp. 103-114). Thieme Medical Publishers.
60. Gillespie KM. Type i diabetes: pathogenesis and prevention. Cmaj. 2006 Jul 18;175(2):165-70.
61. Hyppönen E, Läärä Due east, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a nascence-accomplice study. The Lancet. 2001 Nov 3;358(9292):1500-iii.
62. Rewers Thou, Ludvigsson J. Environmental risk factors for type 1 diabetes. The Lancet. 2022 Jun 4;387(10035):2340-viii.
63. Munger KL, Levin LI, Massa J, Horst R, Orban T, Ascherio A. Preclinical serum 25-hydroxyvitamin D levels and chance of type 1 diabetes in a cohort of US military personnel. American periodical of epidemiology. 2013 Mar ane;177(5):411-9.
64. Promise-Simpson RE. The part of season in the epidemiology of influenza. Epidemiology & Infection. 1981 February;86(1):35-47.
65. Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci Eastward. Epidemic influenza and vitamin D. Epidemiology & Infection. 2006 Dec;134(half-dozen):1129-forty.
66. Ginde AA, Mansbach JM, Camargo CA. Clan betwixt serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Archives of internal medicine. 2009 Feb 23;169(4):384-xc.
67. Urashima One thousand, Segawa T, Okazaki M, Kurihara Yard, Wada Y, Ida H. Randomized trial of vitamin D supplementation to foreclose seasonal influenza A in schoolchildren. The American journal of clinical nutrition. 2010 May 1;91(5):1255-60.
68. Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito South, Ganmaa D, Ginde AA, Goodall EC. Vitamin D supplementation to forbid astute respiratory tract infections: systematic review and meta-assay of individual participant data. BMJ. 2022 Feb 15;356:i6583.
69. Zasloff Yard. Fighting infections with vitamin D. Nature medicine. 2006 April;12(4):388-90.
70. Nnoaham KE, Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. International journal of epidemiology. 2008 Feb 1;37(1):113-9.
71. Chocano-Bedoya P, Ronnenberg AG. Vitamin D and tuberculosis. Nutrition reviews. 2009 May 1;67(five):289-93.
72. Autier P, Gandini South. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Archives of internal medicine. 2007 Sep 10;167(16):1730-7.
73. Giovannucci E. Tin can vitamin D reduce total bloodshed?. Athenaeum of Internal Medicine. 2007 Sep x;167(16):1709-10.
74. Tripkovic L, Lambert H, Hart One thousand, Smith CP, Bucca G, Penson S, Chope G, Hyppönen E, Drupe J, Vieth R, Lanham-New S. Comparing of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. The American journal of clinical nutrition. 2012 Jun 1;95(6):1357-64.
75. Wilson LR, Tripkovic L, Hart KH, Lanham-New SA. Vitamin D deficiency every bit a public health issue: using vitamin D two or vitamin D 3 in future fortification strategies. Proceedings of the Diet Club. 2022 Aug;76(three):392-9.
76. Holick MF. Vitamin D: importance in the prevention of cancers, type ane diabetes, heart disease, and osteoporosis.Am J Clin Nutr. 2004; 79:362-71
77. Holick MF. Vitamin D deficiency.N Engl J Med. 2007; 357:266-81.
78. Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes Five, Kotler G, Lee IM, Manson JE, Costenbader KH. Vitamin D and marine omega three fatty acid supplementation and incident autoimmune illness: VITAL randomized controlled trial. BMJ. 2022 Jan 26;376:e066452.

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